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Of course, smoking cessation and being drug-free, is always desirable in pregnant women. - History of serious disturbances in eating behavior like anorexia or mental bulimia - Bipolar disorder that may be aggravated by the effect of an antidepressant - Benign or malignant tumor in the brain or spinal cord - History of seizures - Individuals who are being weaned to alcohol or tranquilizers zyban smoking The use of this drug during pregnancy is not recommended. A strong motivation has to be present during the start of the therapy.